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Literature summary extracted from

  • Zheng, D.; Wang, G.; Li, S.; Fan, G.C.; Peng, T.
    Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation (2015), Biochim. Biophys. Acta, 1852, 882-892.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpain inhibitor-III completely inhibited by 0.01 mM Mus musculus
3.4.22.52 calpain inhibitor-III completely inhibited by 0.01 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.52 75000
-
 x * 75000, active fragment, SDS-PAGE Mus musculus
3.4.22.52 75000
-
 x * 75000, active fragment, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.52 alpha-spectrin + H2O Mus musculus
-
 ?
-
 ?
3.4.22.52 alpha-spectrin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Mus musculus
-
-
-
3.4.22.52 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 cardiomyocyte
-
 Mus musculus
-
3.4.22.52 H9c2 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 alpha-spectrin + H2O
-
 Mus musculus ?
-
 ?
3.4.22.52 alpha-spectrin + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.52 ? x * 75000, active fragment, SDS-PAGE Mus musculus
3.4.22.52 ? x * 75000, active fragment, SDS-PAGE Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.22.52 Mus musculus cell infection with Ad-capn1 and significantly elevates the protein level of calpain-1 up
3.4.22.52 Rattus norvegicus cell infection with Ad-capn1 and significantly elevates the protein level of calpain-1 up

General Information

EC Number General Information Comment Organism
3.4.22.52 physiological function calpain-1 induces endoplasmic reticulum stress and c-Jun N-terminal protein kinase1/2 activation, thereby mediating apoptosis in cardiomyocytes following hypoxia/reoxygenation. Up-regulation of calpain-1 induces increases in caspase-3 activation and DNA fragmentation, indicative of apoptosis Mus musculus
3.4.22.52 physiological function calpain-1 induces endoplasmic reticulum stress and c-Jun N-terminal protein kinase1/2 activation, thereby mediating apoptosis in cardiomyocytes following hypoxia/reoxygenation. Up-regulation of calpain-1 induces increases in caspase-3 activation and DNA fragmentation, indicative of apoptosis Rattus norvegicus